GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | CLDN2 | chrX:106143394-106174091:+ | 0.26 | 6.02 | 3.46E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | EML5 | chr14:89081205-89259157:- | 0.3 | 6.88 | 1.9E-11 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | EPDR1 | chr7:37960163-37991539:+ | 0.32 | 7.17 | 2.86E-12 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | GGT5 | chr22:24615623-24641110:- | 0.26 | 5.98 | 4.48E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | LRRC42 | chr1:54412037-54433839:+ | -0.23 | -5.96 | 4.79E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | NKX6-1 | chr4:85414436-85419387:- | 0.48 | 8.35 | 7.4E-16 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10983761 | chr9:100553957 | PLCE1 | chr10:95753746-96088146:+ | 0.27 | 6.07 | 2.66E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs6600671 | 1 | rs11249350 | chr1:121178446 | NBPF14 | chr1:148003643-148346791:- | 0.44 | 10.43 | 4.37E-23 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs11249351 | chr1:121171942 | NBPF14 | chr1:148003643-148346791:- | 0.42 | 9.85 | 6.01E-21 | Hip geometry |
| THCA | trans | rs1167827 | 1 | rs1167827 | chr7:75163169 | TRIM74 | chr7:75021265-75040277:+ | -0.34 | -6.76 | 4.14E-11 | Body mass index |
| THCA | trans | rs1056667 | 1 | rs11756120 | chr6:26529808 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.29 | 1.42E-22 | Educational attainment |
| THCA | trans | rs853679 | 1 | rs11965538 | chr6:28239915 | BTN3A2 | chr6:26365398-26378546:+ | -0.5 | -9.8 | 9.06E-21 | Depression |
| THCA | trans | rs6600671 | 1 | rs12047116 | chr1:121185770 | NBPF14 | chr1:148003643-148346791:- | 0.43 | 10.36 | 7.92E-23 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs12145080 | chr1:121185531 | NBPF14 | chr1:148003643-148346791:- | -0.41 | -9.58 | 5.27E-20 | Hip geometry |
| THCA | trans | rs12157904 | 1 | rs12158264 | chr22:38001504 | AP1B1 | chr22:29723671-29784569:- | -0.53 | -5.96 | 4.82E-9 | Response to anti-depressant treatment in major depressive disorder |